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Showing 1 to 12 of 280 entries
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Targeting the HGF-cMET Axis in Hepatocellular Carcinoma.

International journal of hepatology

Venepalli NK, Goff L.
PMID: 23606971
Int J Hepatol. 2013;2013:341636. doi: 10.1155/2013/341636. Epub 2013 Mar 31.

Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor, the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis, morphogenesis, and wound healing. The HGF-cMET axis promotes cell survival, proliferation, migration, and invasion via modulation of...

Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context.

International journal of hepatology

Bioulac-Sage P, Sempoux C, Possenti L, Frulio N, Laumonier H, Laurent C, Chiche L, Frédéric Blanc J, Saric J, Trillaud H, Le Bail B, Balabaud C.
PMID: 23691330
Int J Hepatol. 2013;2013:253261. doi: 10.1155/2013/253261. Epub 2013 Apr 18.

In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65...

Prognostication of Learning Curve on Surgical Management of Vasculobiliary Injuries after Cholecystectomy.

International journal of hepatology

Hafeez Bhatti AB, Dar FS, Zia H, Rafique MS, Khan NY, Salih M, Hassan Shah N.
PMID: 27525124
Int J Hepatol. 2016;2016:2647130. doi: 10.1155/2016/2647130. Epub 2016 Jul 20.

Background. Concomitant vascular injury might adversely impact outcomes after iatrogenic bile duct injury (IBDI). Whether a new HPB center should embark upon repair of complex biliary injuries with associated vascular injuries during learning curve is unknown. The objective of...

Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure.

International journal of hepatology

Tang Y, Li Q, Meng F, Huang X, Li C, Zhou X, Zeng X, He Y, Liu J, Hu X, Hu JF, Li T.
PMID: 27057357
Int J Hepatol. 2016;2016:5452487. doi: 10.1155/2016/5452487. Epub 2016 Feb 28.

Human umbilical cord-derived mesenchymal stem cells (UCMSCs) are particularly attractive cells for cellular and gene therapy in acute liver failure (ALF). However, the efficacy of this cell therapy in animal studies needs to be significantly improved before it can...

A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice.

International journal of hepatology

Bruckbauer A, Banerjee J, Fu L, Li F, Cao Q, Cui X, Wu R, Shi H, Xue B, Zemel MB.
PMID: 28042486
Int J Hepatol. 2016;2016:9185987. doi: 10.1155/2016/9185987. Epub 2016 Nov 30.

Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild...

Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis.

International journal of hepatology

Omar M, Abdel-Razek W, Abo-Raia G, Assem M, El-Azab G.
PMID: 26550493
Int J Hepatol. 2015;2015:309042. doi: 10.1155/2015/309042. Epub 2015 Oct 13.

Background. Serum cystatin C (CysC) was proposed as an effective reflection of the glomerular filtration rate (GFR). However, its role in patients with liver cirrhosis has not been extensively verified especially in the detection of early RI. Patients and...

Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.

International journal of hepatology

Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K.
PMID: 24868471
Int J Hepatol. 2014;2014:584650. doi: 10.1155/2014/584650. Epub 2014 Apr 27.

It is known that the interleukin-4 receptor α (IL-4R α ) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4R α -lytic hybrid peptide composed of binding peptide to IL-4R α and...

Pretreatment of Small-for-Size Grafts In Vivo by γ -Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation.

International journal of hepatology

Hori T, Uemoto S, Walden LB, Chen F, Baine AM, Hata T, Nguyen JH.
PMID: 24223309
Int J Hepatol. 2013;2013:149123. doi: 10.1155/2013/149123. Epub 2013 Oct 08.

Background. Graft pretreatment to limit postoperative damage has the advantage of overcoming a current issue in liver transplantation (LT). The strategic potential of graft pretreatment in vivo by a specific agonist for γ -aminobutyric acid receptor (GABAR) was investigated...

Growing Up: Not an Easy Transition-Perspectives of Patients and Parents regarding Transfer from a Pediatric Liver Transplant Center to Adult Care.

International journal of hepatology

Chandra S, Luetkemeyer S, Romero R, Gupta NA.
PMID: 26682071
Int J Hepatol. 2015;2015:765957. doi: 10.1155/2015/765957. Epub 2015 Nov 22.

The transition from pediatric to adult care is a critical time when children with chronic illness sustain high morbidity and mortality. Transition services need to be focused on the adolescents' needs, which may differ from those perceived by healthcare...

Impact of pretransplant hepatic encephalopathy on liver posttransplantation outcomes.

International journal of hepatology

Teperman LW.
PMID: 24324895
Int J Hepatol. 2013;2013:952828. doi: 10.1155/2013/952828. Epub 2013 Nov 13.

Patients with cirrhosis commonly experience hepatic encephalopathy (HE), a condition associated with alterations in behavior, cognitive function, consciousness, and neuromuscular function of varying severity. HE occurring before liver transplant can have a substantial negative impact on posttransplant outcomes, and...

Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia.

International journal of hepatology

Sato Y, Harada K, Sasaki M, Nakanuma Y.
PMID: 24860672
Int J Hepatol. 2014;2014:678260. doi: 10.1155/2014/678260. Epub 2014 Apr 10.

Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar/perihilar and extrahepatic cholangiocarcinoma. BilIN represents the process of multistep cholangiocarcinogenesis and is the biliary counterpart of pancreatic intraepithelial neoplasia (PanIN). This study was performed to clarify the histological characteristics...

Calcium signalling and liver regeneration.

International journal of hepatology

Garcin I, Tordjmann T.
PMID: 23119169
Int J Hepatol. 2012;2012:630670. doi: 10.1155/2012/630670. Epub 2012 Oct 16.

After partial hepatectomy (PH) the initial mass of the organ is restored through a complex network of cellular interactions that orchestrate both proliferative and hepatoprotective signalling cascades. Among agonists involved in this network many of them drive Ca(2+) movements....

Showing 1 to 12 of 280 entries